- Metal Gear Solid 3: Snake Eater
- Metal Gear Solid: Portable Ops
- Metal Gear Solid: Peace Walker
- Metal Gear Solid V: Ground Zeroes
- Metal Gear Solid V: The Phantom Pain (as Venom Snake)
Jack was once the apprentice of The Boss, a legendary war hero who single-handedly helped win World War 2 for the Allied. Jack joined The Boss's FOX unit, a small CIA infiltration team, and, under the codename Naked Snake, was sent to rescue a captured Russian scientist. Snake however learned The Boss had defected to the Soviet union, and to prevent nuclear war, was forced to execute his mother-figure in Operation Snake Eater, leaving him a bitter husk. Snake, now known as Big Boss, spent the rest of his life forging military organizations like FOXHOUND and the Diamond Dogs, and was the unwilling genome template for Solid Snake and Liquid Snake.